Mechanisms Underlying the Anti-inflammatory Effects of the Ca2+/Calmodulin Antagonist CV-159 in Cultured Vascular Smooth Muscle Cells

• Main Authors: Tatsuya Usui (Author), Hideyuki Yamawaki (Author), Masato Kamibayashi (Author), Muneyoshi Okada (Author), Yukio Hara (Author)
• Format: Knjiga
• Izdano: Elsevier, 2010-01-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

CV-159 is a unique dihydropyridine Ca2+antagonist with an anti-calmodulin (CaM) action. A pathogenic feature of atherosclerosis is vascular inflammatory change. In the present study, we examined whether CV-159 exerts protective effects on smooth muscle inflammatory responses. After pretreatment of r...