Pim1 knockout alleviates sarcopenia in aging mice via reducing adipogenic differentiation of PDGFRα+ mesenchymal progenitors

• Main Authors: Guo‐kai Shang (Author), Lu Han (Author), Zhi‐hao Wang (Author), Ming Song (Author), Di Wang (Author), Yan‐min Tan (Author), Yi‐hui Li (Author), Yu‐lin Li (Author), Wei Zhang (Author), Ming Zhong (Author)
• Format: Book
• Published: Wiley, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Sarcopenia widely exists in elderly people and triggers numerous age‐related events. The essential pathologic change lies in the increased intramuscular adipose tissue after aging with no exception to non‐obese objects. Pim1 appears to be associated with adipogenic differentiatio...