Single-cell and spatial transcriptomics reveal alterations in trophoblasts at invasion sites and disturbed myometrial immune microenvironment in placenta accreta spectrum disorders

• Main Authors: Kaiyuan Ji (Author), Yunshan Chen (Author), Xiuyu Pan (Author), Lina Chen (Author), Xiaodi Wang (Author), Bolun Wen (Author), Junjie Bao (Author), Junmin Zhong (Author), Zi Lv (Author), Zheng Zheng (Author), Huishu Liu (Author)
• Format: Book
• Published: BMC, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Placenta accreta spectrum disorders (PAS) are a severe complication characterized by abnormal trophoblast invasion into the myometrium. The underlying mechanisms of PAS involve a complex interplay of various cell types and molecular pathways. Despite its significance, both the ch...