Impaired Brain Mitochondrial Bioenergetics in the Ts65Dn Mouse Model of Down Syndrome Is Restored by Neonatal Treatment with the Polyphenol 7,8-Dihydroxyflavone

Down syndrome (DS), a major genetic cause of intellectual disability, is characterized by numerous neurodevelopmental defects. Previous in vitro studies highlighted a relationship between bioenergetic dysfunction and reduced neurogenesis in progenitor cells from the Ts65Dn mouse model of DS, suggest...

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Main Authors: Daniela Valenti (Author), Fiorenza Stagni (Author), Marco Emili (Author), Sandra Guidi (Author), Renata Bartesaghi (Author), Rosa Anna Vacca (Author)
Format: Book
Published: MDPI AG, 2021-12-01T00:00:00Z.
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3rd Floor Main Library

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