A Primate APOL1 Variant That Kills Trypanosoma brucei gambiense.

• Main Authors: Anneli Cooper (Author), Paul Capewell (Author), Caroline Clucas (Author), Nicola Veitch (Author), William Weir (Author), Russell Thomson (Author), Jayne Raper (Author), Annette MacLeod (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Humans are protected against infection from most African trypanosomes by lipoprotein complexes present in serum that contain the trypanolytic pore-forming protein, Apolipoprotein L1 (APOL1). The human-infective trypanosomes, Trypanosoma brucei rhodesiense in East Africa and T. b. gambiense in West A...