DEVELOPMENT, IN-VITRO AND EX-VIVO EVALUATION OF MUCO-ADHESIVE BUCCAL TABLETS OF HYDRALAZINE HYDROCHLORIDE

Abstract Hydralazine hydrochloride is an anti-hypertensive drug. The drug has poor oral bioavailability (BA) of about 30- 50% due to extensive first-pass metabolism. Hence, the buccal delivery was used to enhance the BA of hydralazine hydrochloride. Buccal muco-adhesive tablets were prepared by dire...

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Main Authors: Kumara Swamy Samanthula (Author), Mahendra Kumar CB (Author), Agaiah Goud Bairi (Author), Shobha Rani Satla (Author)
Format: Book
Published: Universidade de São Paulo, 2022-04-01T00:00:00Z.
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