DEVELOPMENT, IN-VITRO AND EX-VIVO EVALUATION OF MUCO-ADHESIVE BUCCAL TABLETS OF HYDRALAZINE HYDROCHLORIDE
Abstract Hydralazine hydrochloride is an anti-hypertensive drug. The drug has poor oral bioavailability (BA) of about 30- 50% due to extensive first-pass metabolism. Hence, the buccal delivery was used to enhance the BA of hydralazine hydrochloride. Buccal muco-adhesive tablets were prepared by dire...
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Universidade de São Paulo,
2022-04-01T00:00:00Z.
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A1234.567 |
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