Design, Synthesis, and Evaluation of Niclosamide Analogs as Therapeutic Agents for Enzalutamide-Resistant Prostate Cancer

• Main Authors: Borui Kang (Author), Madhusoodanan Mottamal (Author), Qiu Zhong (Author), Melyssa Bratton (Author), Changde Zhang (Author), Shanchun Guo (Author), Ahamed Hossain (Author), Peng Ma (Author), Qiang Zhang (Author), Guangdi Wang (Author), Florastina Payton-Stewart (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Niclosamide effectively downregulates androgen receptor variants (AR-Vs) for treating enzalutamide and abiraterone-resistant prostate cancer. However, the poor pharmaceutical properties of niclosamide due to its solubility and metabolic instability have limited its clinical utility as a systemic tre...