Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis

• Main Authors: Peter Kirwan (Author), Richard G. Kay (Author), Bas Brouwers (Author), Vicente Herranz-Pérez (Author), Magdalena Jura (Author), Pierre Larraufie (Author), Julie Jerber (Author), Jason Pembroke (Author), Theresa Bartels (Author), Anne White (Author), Fiona M. Gribble (Author), Frank Reimann (Author), I. Sadaf Farooqi (Author), Stephen O'Rahilly (Author), Florian T. Merkle (Author)
• Format: Book
• Published: Elsevier, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The lack of pro-opiomelanocortin (POMC)-derived melanocortin peptides results in hypoadrenalism and severe obesity in both humans and rodents that is treatable with synthetic melanocortins. However, there are significant differences in POMC processing between humans and rodents, and littl...