Alterations of DNA methylation and expression of genes related to thyroid hormone metabolism in colon epithelium of obese patients

• Main Authors: Ghazaleh Shimi (Author), Katayoun Pourvali (Author), Arman Ghorbani (Author), Sajad Nooshin (Author), Shohreh Zare Karizi (Author), Reza Iranirad (Author), Hamid Zand (Author)
• Format: Book
• Published: BMC, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Colorectal cancer is common among obese individuals. The purpose of the current study was to determine changes in DNA methylation status and mRNA expression of thyroid hormone receptor beta (THRB), as a tumor suppressor, and thyroid hormone inactivating enzyme, type 3 deiodinase...