Pan-Phosphodiesterase Inhibitors Attenuate TGF-β-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation

• Main Authors: Katarzyna Wójcik-Pszczoła (Author), Grażyna Chłoń-Rzepa (Author), Agnieszka Jankowska (Author), Bruno Ferreira (Author), Paulina Koczurkiewicz-Adamczyk (Author), Elżbieta Pękala (Author), Elżbieta Wyska (Author), Krzysztof Pociecha (Author), Reinoud Gosens (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2022-03-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Airway remodeling is a pathological process that accompanies many chronic lung diseases. One of the important players in this process are epithelial cells, which under the influence of pro-inflammatory and pro-fibrotic factors present in the airway niche, actively participate in the remodeling proce...