T cell--associated immunoregulation and antiviral effect of oxymatrine in hydrodynamic injection HBV mouse model

• Main Authors: Xiuxiu Sang (Author), Ruilin Wang (Author), Yanzhong Han (Author), Cong'en Zhang (Author), Honghui Shen (Author), Zhirui Yang (Author), Yin Xiong (Author), Huimin Liu (Author), Shijing Liu (Author), Ruisheng Li (Author), Ruichuang Yang (Author), Jiabo Wang (Author), Xuejun Wang (Author), Zhaofang Bai (Author), Xiaohe Xiao (Author)
• Format: Book
• Published: Elsevier, 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although oxymatrine (OMT) has been shown to directly inhibit the replication of hepatitis B virus (HBV) in vitro, limited research has been done with this drug in vivo. In the present study, the antiviral effect of OMT was investigated in an immunocompetent mouse model of chronic HBV infection. The...