Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice

• Main Authors: Rachel M.B. Bell (Author), Elisa Villalobos (Author), Mark Nixon (Author), Allende Miguelez-Crespo (Author), Lee Murphy (Author), Angie Fawkes (Author), Audrey Coutts (Author), Matthew G.F. Sharp (Author), Martha V. Koerner (Author), Emma Allan (Author), Onno C. Meijer (Author), Renè Houtman (Author), Alex Odermatt (Author), Katharina R. Beck (Author), Scott G. Denham (Author), Patricia Lee (Author), Natalie Z.M. Homer (Author), Brian R. Walker (Author), Ruth A. Morgan (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Carbonyl reductase 1 (Cbr1), a recently discovered contributor to tissue glucocorticoid metabolism converting corticosterone to 20β-dihydrocorticosterone (20β-DHB), is upregulated in adipose tissue of obese humans and mice and may contribute to cardiometabolic complications of obesity. Th...