Bifunctional molecules targeting SARS-CoV-2 spike and the polymeric Ig receptor display neutralization activity and mucosal enrichment

• Main Authors: Ian White (Author), Ninkka Tamot (Author), Rajitha Doddareddy (Author), Jason Ho (Author), Qun Jiao (Author), Paul B. Harvilla (Author), Tong-Yuan Yang (Author), Brian Geist (Author), M. Jack Borrok (Author), Matthew D. Truppo (Author), Rajkumar Ganesan (Author), Partha Chowdhury (Author), Adam Zwolak (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The global health crisis and economic tolls of COVID-19 necessitate a panoply of strategies to treat SARS-CoV-2 infection. To date, few treatment options exist, although neutralizing antibodies against the spike glycoprotein have proven to be effective. Because infection is initiated at the mucosa a...