An Efficient Bivalent Cyclic RGD-PIK3CB siRNA Conjugate for Specific Targeted Therapy against Glioblastoma In Vitro and In Vivo

• Main Authors: Bohong Cen (Author), Yuanyi Wei (Author), Wen Huang (Author), Muzhou Teng (Author), Shuai He (Author), Jianlong Li (Author), Wei Wang (Author), Guolin He (Author), Xin Bai (Author), Xiaoxia Liu (Author), Yawei Yuan (Author), Xinghua Pan (Author), Aimin Ji (Author)
• Format: Book
• Published: Elsevier, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The PI3K-AKT-mTOR-signaling pathway is frequently activated in glioblastoma (GBM). Inhibition of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta (PIK3CB)/p110β (a PI3K catalytic isoform) by RNAi substantially suppresses GBM growth with less toxicity to normal astrocytes. Howeve...