An Efficient Bivalent Cyclic RGD-PIK3CB siRNA Conjugate for Specific Targeted Therapy against Glioblastoma In Vitro and In Vivo
The PI3K-AKT-mTOR-signaling pathway is frequently activated in glioblastoma (GBM). Inhibition of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta (PIK3CB)/p110β (a PI3K catalytic isoform) by RNAi substantially suppresses GBM growth with less toxicity to normal astrocytes. Howeve...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2018-12-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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