Investigation of α,ω-Disubstituted Polyamine-Cholic Acid Conjugates Identifies Hyodeoxycholic and Chenodeoxycholic Scaffolds as Non-Toxic, Potent Antimicrobials

• Hauptverfasser: Kenneth Sue (Verfasst von), Melissa M. Cadelis (Verfasst von), Thomas Troia (Verfasst von), Florent Rouvier (Verfasst von), Marie-Lise Bo (Verfasst von), Jean Michel Brunel (Verfasst von), Brent R. Copp (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2023-02-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

With the increased incidence of antibiotic resistance, the discovery and development of new antibacterials is of increasing importance and urgency. The report of the natural product antibiotic squalamine in 1993 has stimulated a lot of interest in the study of structurally simplified cholic acid-pol...