Investigation of α,ω-Disubstituted Polyamine-Cholic Acid Conjugates Identifies Hyodeoxycholic and Chenodeoxycholic Scaffolds as Non-Toxic, Potent Antimicrobials

• Κύριοι συγγραφείς: Kenneth Sue (Συγγραφέας), Melissa M. Cadelis (Συγγραφέας), Thomas Troia (Συγγραφέας), Florent Rouvier (Συγγραφέας), Marie-Lise Bo (Συγγραφέας), Jean Michel Brunel (Συγγραφέας), Brent R. Copp (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2023-02-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

With the increased incidence of antibiotic resistance, the discovery and development of new antibacterials is of increasing importance and urgency. The report of the natural product antibiotic squalamine in 1993 has stimulated a lot of interest in the study of structurally simplified cholic acid-pol...