Investigation of α,ω-Disubstituted Polyamine-Cholic Acid Conjugates Identifies Hyodeoxycholic and Chenodeoxycholic Scaffolds as Non-Toxic, Potent Antimicrobials

• Autores principales: Kenneth Sue (Autor), Melissa M. Cadelis (Autor), Thomas Troia (Autor), Florent Rouvier (Autor), Marie-Lise Bo (Autor), Jean Michel Brunel (Autor), Brent R. Copp (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2023-02-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

With the increased incidence of antibiotic resistance, the discovery and development of new antibacterials is of increasing importance and urgency. The report of the natural product antibiotic squalamine in 1993 has stimulated a lot of interest in the study of structurally simplified cholic acid-pol...