Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy

• Main Authors: Emily J. Jones (Author), Zoe J. Matthews (Author), Lejla Gul (Author), Padhmanand Sudhakar (Author), Agatha Treveil (Author), Devina Divekar (Author), Jasmine Buck (Author), Tomasz Wrzesinski (Author), Matthew Jefferson (Author), Stuart D. Armstrong (Author), Lindsay J. Hall (Author), Alastair J. M. Watson (Author), Simon R. Carding (Author), Wilfried Haerty (Author), Federica Di Palma (Author), Ulrike Mayer (Author), Penny P. Powell (Author), Isabelle Hautefort (Author), Tom Wileman (Author), Tamas Korcsmaros (Author)
• Format: Book
• Published: The Company of Biologists, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Paneth cells are key epithelial cells that provide an antimicrobial barrier and maintain integrity of the small-intestinal stem cell niche. Paneth cell abnormalities are unfortunately detrimental to gut health and are often associated with digestive pathologies such as Crohn's disease or infect...