Leverage of nuclease-deficient CasX for preventing pathological angiogenesis

• Main Authors: Haote Han (Author), Yanhui Yang (Author), Yunjuan Jiao (Author), Hui Qi (Author), Zhuo Han (Author), Luping Wang (Author), Lijun Dong (Author), Jingkui Tian (Author), Bart Vanhaesebroeck (Author), Xiaopeng Li (Author), Junwen Liu (Author), Gaoen Ma (Author), Hetian Lei (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gene editing with a CRISPR/Cas system is a novel potential strategy for treating human diseases. Pharmacological inhibition of phosphoinositide 3-kinase (PI3K) δ suppresses retinal angiogenesis in a mouse model of oxygen-induced retinopathy. Here we show that an innovative system of adeno-associated...