Development of ion-triggered in situ gel containing ketoconazole/hydroxypropyl-β-cyclodextrin for ocular delivery: in vitro and in vivo evaluation

• Päätekijät: Huiyun Xia (Tekijä), Jingjing Yang (Tekijä), Fei Song (Tekijä), Guojuan Pu (Tekijä), Fudan Dong (Tekijä), Zhen Liang (Tekijä), Junjie Zhang (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

The application of ketoconazole (KET) in ocular drug delivery is restricted by its poor aqueous solubility though its broad-spectrum antifungal activity. The aim of this study is to develop an ion-sensitive in situ gel (ISG) of KET to promote its ocular bioavailability in topical application. The so...