Discovery of a Potent and Orally Active Dual GPBAR1/CysLT1R Modulator for the Treatment of Metabolic Fatty Liver Disease

Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are two highly prevalent human diseases caused by excessive fat deposition in the liver. Although multiple approaches have been suggested, NAFLD/NASH remains an unmet clinical need. Here, we report the discovery of a no...

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Main Authors: Stefano Fiorucci (Author), Pasquale Rapacciuolo (Author), Bianca Fiorillo (Author), Rosalinda Roselli (Author), Silvia Marchianò (Author), Cristina Di Giorgio (Author), Martina Bordoni (Author), Rachele Bellini (Author), Chiara Cassiano (Author), Paolo Conflitti (Author), Bruno Catalanotti (Author), Vittorio Limongelli (Author), Valentina Sepe (Author), Michele Biagioli (Author), Angela Zampella (Author)
格式: 圖書
出版: Frontiers Media S.A., 2022-04-01T00:00:00Z.
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索引號: A1234.567
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