Discovery of novel exceptionally potent and orally active c-MET PROTACs for the treatment of tumors with MET alterations

Various c-mesenchymal-to-epithelial transition (c-MET) inhibitors are effective in the treatment of non-small cell lung cancer; however, the inevitable drug resistance remains a challenge, limiting their clinical efficacy. Therefore, novel strategies targeting c-MET are urgently required. Herein, th...

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Main Authors: Pengyun Li (Author), Changkai Jia (Author), Zhiya Fan (Author), Xiaotong Hu (Author), Wenjuan Zhang (Author), Ke Liu (Author), Shiyang Sun (Author), Haoxin Guo (Author), Ning Yang (Author), Maoxiang Zhu (Author), Xiaomei Zhuang (Author), Junhai Xiao (Author), Zhibing Zheng (Author), Song Li (Author)
Format: Book
Published: Elsevier, 2023-06-01T00:00:00Z.
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