Design, synthesis, biological evaluation and molecular docking study of 2,4-diarylimidazoles and 2,4-bis(benzyloxy)-5-arylpyrimidines as novel HSP90 N-terminal inhibitors

• Main Authors: Man Yang (Author), Chenyao Li (Author), Yajing Li (Author), Chen Cheng (Author), Meiyun Shi (Author), Lei Yin (Author), Hongyu Xue (Author), Yajun Liu (Author)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The molecular chaperone HSP90 plays an essential role in cancer occurrence and development. Therefore, it is an important target for the development of anticancer drugs. 1,3-Dibenzyl-2-aryl imidazolidine (8) is a previously reported inhibitor of HSP90; however, its anticancer activity is poor. In th...