A lipid nanoparticle-based oligodendrocyte-specific mRNA therapy

• Main Authors: Masanori Sawamura (Author), Kiyoshi Tachikawa (Author), Rie Hikawa (Author), Hisako Akiyama (Author), Seiji Kaji (Author), Ken Yasuda (Author), Angel I. Leu (Author), Hyojung Hong (Author), Rajesh Mukthavaram (Author), Pad Chivukula (Author), Hodaka Yamakado (Author), Yoshio Hirabayashi (Author), Ryosuke Takahashi (Author), Shu-ichi Matsuzawa (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite the wide range of applications of mRNA therapies, major difficulties exist in the efficient delivery of mRNA into oligodendrocytes, a type of glial cell in the brain. Commonly used viral vectors are not efficient in transforming oligodendrocytes. In this study, we introduced mRNAs into oligo...