Interference with megalin expression/endocytic function by montelukast mitigates gentamicin nephrotoxicity: Downregulation of ClC-5 expression

• मुख्य लेखकों: Amany A. Azouz (लेखक), Dina A. Hanna (लेखक), Ali A. Abo-Saif (लेखक), Basim Anwar Shehata Messiha (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2022-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Megalin receptor-mediated endocytosis participates a crucial role in gentamicin (GM) uptake, accumulation, and toxicity. In this study, we investigated the potential effects of montelukast (MLK) on megalin expression/endocytic function against GM nephrotoxicity. Male Wistar rats were administered GM...