Interference with megalin expression/endocytic function by montelukast mitigates gentamicin nephrotoxicity: Downregulation of ClC-5 expression

• Main Authors: Amany A. Azouz (Author), Dina A. Hanna (Author), Ali A. Abo-Saif (Author), Basim Anwar Shehata Messiha (Author)
• Formato: Livro
• Publicado em: Elsevier, 2022-02-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Megalin receptor-mediated endocytosis participates a crucial role in gentamicin (GM) uptake, accumulation, and toxicity. In this study, we investigated the potential effects of montelukast (MLK) on megalin expression/endocytic function against GM nephrotoxicity. Male Wistar rats were administered GM...