Pharmacokinetics and tissue distribution of vigabatrin enantiomers in rats

• Main Authors: Qiang Zheng (Author), Shuai He (Author), Song-Lin Xu (Author), Meng-Die Ma (Author), Min Fan (Author), Jin-Fang Ge (Author)
• Format: Book
• Published: Elsevier, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: To investigate the pharmacokinetics and tissue distribution of VGB racemate and its single enantiomers, and explore the potential of clinic development for single enantiomer S-VGB. Methods: In the pharmacokinetics study, male Sprague-Dawley rats were gavaged with VGB racemate or its single...