Validated DBS method for filgotinib quantitation in rat dried blood spots and its application to a pharmacokinetic study in rats

• मुख्य लेखकों: Abhishek Dixit (लेखक), Vinay Kiran (लेखक), Bhavesh Babulal Gabani (लेखक), Ramesh Mullangi (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: International Association of Physical Chemists (IAPC), 2020-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Filgotinib is a selective JAK1 (Janus kinase) inhibitor, showed efficacy in patients suffering from moderate-to-severe rheumatoid arthritis. In this paper, we present the data on the development and validation of a sensitive, selective and high-throughput LC-MS/MS (liquid chromatography with tandem...