IPEC-J2 rMdr1a, a New Cell Line with Functional Expression of Rat P-glycoprotein Encoded by Rat Mdr1a for Drug Screening Purposes

• मुख्य लेखकों: Lasse Saaby (लेखक), Josefine Trasborg (लेखक), Mikkel A. Rasmussen (लेखक), Bjørn Holst (लेखक), Birger Brodin (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2020-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The efflux pump P-glycoprotein (P-gp) affects drug distribution after absorption in humans and animals. P-gp is encoded by the multidrug resistance gene (MDR1) gene in humans, while rodents (the most common preclinical animal model) express the two isoforms Mdr1a and Mdr1b. Differences in substrate...