Fate of Tableted Freeze-Dried siRNA Lipoplexes in Gastrointestinal Environment

• Main Authors: Asad Ur Rehman (Author), Virginie Busignies (Author), Marcela Coelho Silva Ribeiro (Author), Nayara Almeida Lage (Author), Pierre Tchoreloff (Author), Virginie Escriou (Author), Christine Charrueau (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The incorporation of siRNA into nanocarriers is mandatory to facilitate its intracellular delivery, as siRNA itself cannot enter cells. However, the incorporation of these nanocarriers into oral, solid dosage forms and their fate in the gastrointestinal environment is yet to be explored. In the pres...