An inhibitory effect of tumor necrosis factor-alpha antagonist to gene expression in monocrotaline-induced pulmonary hypertensive rats model

• Main Authors: Jung Hyun Kwon (Author), Kwan Chang Kim (Author), Min-Sun Cho (Author), Hae Soon Kim (Author), Sejung Sohn (Author), Young Mi Hong (Author)
• Format: Book
• Published: Korean Pediatric Society, 2013-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PurposeTumor necrosis factor (TNF)-α is thought to contribute to pulmonary hypertension. We aimed to investigate the effect of infliximab (TNF-α antagonist) treatment on pathologic findings and gene expression in a monocrotaline-induced pulmonary hypertension rat model.MethodsSix-week-old male Sprag...