Limiting glucocorticoid secretion increases the anorexigenic property of Exendin-4

• Main Authors: Shin J. Lee (Author), Katharina Diener (Author), Sharon Kaufman (Author), Jean-Philippe Krieger (Author), Klaus G. Pettersen (Author), Nino Jejelava (Author), Myrtha Arnold (Author), Alan G. Watts (Author), Wolfgang Langhans (Author)
• Format: Book
• Published: Elsevier, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Glucagon-like peptide-1 (GLP-1) analogs are attractive options for the treatment of type II diabetes and obesity because of their incretin and anorexigenic effects. Peripheral administration of the GLP-1R agonist Exendin-4 (Ex-4) also increases glucocorticoid secretion in rodents and huma...