Rapid, label‐free enrichment of lymphocytes in a closed system using a flow‐through microfluidic device

• Main Authors: Anton Mukhamedshin (Author), Riley C. Reddington (Author), Mai T. P. Dinh (Author), Kumar Abhishek (Author), Mubasher Iqbal (Author), Marc Manheim (Author), Sean C. Gifford (Author), Sergey S. Shevkoplyas (Author)
• Format: Book
• Published: Wiley, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The majority of adoptive cellular therapies are produced from peripheral mononuclear cells obtained via leukapheresis and further enriched for the cells of interest (e.g., T cells). Here, we present a first‐of‐its‐kind closed system, which effectively removes ~85% of monocytes and ~88% of p...