α-1 Antitrypsin Inhibits RANKL-induced Osteoclast Formation and Functions

• Main Authors: Mohammad Ahsanul Akbar (Author), David Nardo (Author), Mong-Jen Chen (Author), Ahmed S. Elshikha (Author), Rubina Ahamed (Author), Eslam M. Elsayed (Author), Claire Bigot (Author), L. Shannon Holliday (Author), Sihong Song (Author)
• Format: Book
• Published: BMC, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Osteoporosis is a global public health problem affecting more than 200 million people worldwide. We previously showed that treatment with α-1 antitrypsin (AAT), a multifunctional protein with antiinflammatory properties, mitigated bone loss in an ovariectomized mouse model. However, the und...