Introduction of pyrrolidineoxy or piperidineamino group at the 4-position of quinazoline leading to novel quinazoline-based phosphoinositide 3-kinase delta (PI3Kδ) inhibitors

• Glavni autori: Minhang Xin (Autor), Weiming Duan (Autor), Yifan Feng (Autor), Yuan-Yuan Hei (Autor), Hao Zhang (Autor), Ying Shen (Autor), Hong-Yi Zhao (Autor), Shuai Mao (Autor), San-Qi Zhang (Autor)
• Format: Knjiga
• Izdano: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Phosphoinositide 3-kinase Delta (PI3Kδ) plays a key role in B-cell signal transduction and inhibition of PI3Kδ was confirmed to have clinical benefit in certain types of activation of B-cell malignancies. Herein, we reported a novel series of 4-pyrrolidineoxy or 4-piperidineamino substituted quinazo...