A tripeptidyl peptidase 1 is a binding partner of the Golgi pH regulator (GPHR) in Dictyostelium

• Main Authors: Maria Stumpf (Author), Rolf Müller (Author), Berthold Gaßen (Author), Regina Wehrstedt (Author), Petra Fey (Author), Malte A. Karow (Author), Ludwig Eichinger (Author), Gernot Glöckner (Author), Angelika A. Noegel (Author)
• Format: Book
• Published: The Company of Biologists, 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mutations in tripeptidyl peptidase 1 (TPP1) have been associated with late infantile neuronal ceroid lipofuscinosis (NCL), a neurodegenerative disorder. TPP1 is a lysosomal serine protease, which removes tripeptides from the N-terminus of proteins and is composed of an N-terminal prodomain and a cat...