ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype

• Main Authors: Yulia Haim (Author), Matthias Blüher (Author), Daniel Konrad (Author), Nir Goldstein (Author), Nora Klöting (Author), Ilana Harman-Boehm (Author), Boris Kirshtein (Author), Doron Ginsberg (Author), Tanya Tarnovscki (Author), Yftach Gepner (Author), Iris Shai (Author), Assaf Rudich (Author)
• Format: Book
• Published: Elsevier, 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Obesity variably disrupts human health, but molecular-based patients' health-risk stratification is limited. Adipose tissue (AT) stresses may link obesity with metabolic dysfunction, but how they signal in humans remains poorly-characterized. We hypothesized that a transcriptional AT...