2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases

We have carried out the design, synthesis, and evaluation of a small library of 2-aminobenzoxazole-appended coumarins as novel inhibitors of tumour-related CAs IX and XII. Substituents on C-3 and/or C-4 positions of the coumarin scaffold, and on the benzoxazole moiety, together with the length of th...

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Main Authors: Alma Fuentes-Aguilar (Author), Penélope Merino-Montiel (Author), Sara Montiel-Smith (Author), Socorro Meza-Reyes (Author), José Luis Vega-Báez (Author), Adrián Puerta (Author), Miguel X. Fernandes (Author), José M. Padrón (Author), Andrea Petreni (Author), Alessio Nocentini (Author), Claudiu T. Supuran (Author), Óscar López (Author), José G. Fernández-Bolaños (Author)
Formato: Livro
Publicado em: Taylor & Francis Group, 2022-01-01T00:00:00Z.
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