Explaining the Release Mechanism of Ritonavir/PVPVA Amorphous Solid Dispersions

• Main Authors: Adrian Krummnow (Author), Andreas Danzer (Author), Kristin Voges (Author), Stefanie Dohrn (Author), Samuel O. Kyeremateng (Author), Matthias Degenhardt (Author), Gabriele Sadowski (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In amorphous solid dispersions (ASDs), an active pharmaceutical ingredient (API) is dissolved on a molecular level in a polymeric matrix. The API is expected to be released from the ASD upon dissolution in aqueous media. However, a series of earlier works observed a drastic collapse of the API relea...