DNA Aptamers against Vaccinia-Related Kinase (VRK) 1 Block Proliferation in MCF7 Breast Cancer Cells

• Główni autorzy: Rebeca Carrión-Marchante (Autor), Valerio Frezza (Autor), Ana Salgado-Figueroa (Autor), M. Isabel Pérez-Morgado (Autor), M. Elena Martín (Autor), Víctor M. González (Autor)
• Format: Książka
• Wydane: MDPI AG, 2021-05-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Vaccinia-related kinase (VRK) 1 is a serin/threonine kinase that plays an important role in DNA damage response (DDR), phosphorylating some proteins involved in this process such as 53BP1, NBS1 or H2AX, and in the cell cycle progression. In addition, VRK1 is overexpressed in many cancer types and it...