Antisense Oligonucleotides Reduce RNA Foci in Spinocerebellar Ataxia 36 Patient iPSCs

• Main Authors: Kosuke Matsuzono (Author), Keiko Imamura (Author), Nagahisa Murakami (Author), Kayoko Tsukita (Author), Takuya Yamamoto (Author), Yuishin Izumi (Author), Ryuji Kaji (Author), Yasuyuki Ohta (Author), Toru Yamashita (Author), Koji Abe (Author), Haruhisa Inoue (Author)
• Format: Book
• Published: Elsevier, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Spinocerebellar ataxia type 36 is a late-onset, slowly progressive cerebellar syndrome with motor neuron degeneration that is caused by expansions of a hexanucleotide repeat (GGCCTG) in the noncoding region of NOP56 gene, with a histopathological feature of RNA foci formation in postmortem tissues....