Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-Syk-ceramide dependent mechanism

• Main Authors: Vlad Serbulea (Author), Clint M. Upchurch (Author), Katelyn W. Ahern (Author), Gael Bories (Author), Paxton Voigt (Author), Dory E. DeWeese (Author), Akshaya K. Meher (Author), Thurl E. Harris (Author), Norbert Leitinger (Author)
• Format: Book
• Published: Elsevier, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Macrophages control tissue homeostasis and inflammation by sensing and responding to environmental cues. However, the metabolic adaptation of macrophages to oxidative tissue damage and its translation into inflammatory mechanisms remains enigmatic. Methods: Here we identify the critical r...