miRNA-98-5p Targeting IGF2BP1 Induces Mesenchymal Stem Cell Apoptosis by Modulating PI3K/Akt and p53 in Immune Thrombocytopenia

• Main Authors: Yanan Wang (Author), Jiamin Zhang (Author), Yan Su (Author), Chencong Wang (Author), Gaochao Zhang (Author), Xiao Liu (Author), Qi Chen (Author), Meng Lv (Author), Yingjun Chang (Author), Jun Peng (Author), Ming Hou (Author), Xiaojun Huang (Author), Xiaohui Zhang (Author)
• Format: Book
• Published: Elsevier, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immune thrombocytopenia (ITP) is a common hematological autoimmune disease, in which defective mesenchymal stem cells (MSCs) are potentially involved. Our previous study suggested that MSCs in ITP patients displayed enhanced apoptosis. MicroRNAs (miRNAs) play important roles in ITP by affecting mega...