Design, synthesis and structure-activity relationship (SAR) studies of an unusual class of non-cationic fatty amine-tripeptide conjugates as novel synthetic antimicrobial agents

• Main Authors: Noelia Hernández-Ortiz (Author), Pedro A. Sánchez-Murcia (Author), Celia Gil-Campillo (Author), Mirian Domenech (Author), Daniel Lucena-Agell (Author), Rafael Hortigüela (Author), Sonsoles Velázquez (Author), María José Camarasa (Author), Noemí Bustamante (Author), Sonia de Castro (Author), Margarita Menéndez (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cationic ultrashort lipopeptides (USLPs) are promising antimicrobial candidates to combat multidrug-resistant bacteria. Using DICAMs, a newly synthesized family of tripeptides with net charges from −2 to +1 and a fatty amine conjugated to the C-terminus, we demonstrate that anionic and neutral zwitt...