Design, synthesis and structure-activity relationship (SAR) studies of an unusual class of non-cationic fatty amine-tripeptide conjugates as novel synthetic antimicrobial agents

• Główni autorzy: Noelia Hernández-Ortiz (Autor), Pedro A. Sánchez-Murcia (Autor), Celia Gil-Campillo (Autor), Mirian Domenech (Autor), Daniel Lucena-Agell (Autor), Rafael Hortigüela (Autor), Sonsoles Velázquez (Autor), María José Camarasa (Autor), Noemí Bustamante (Autor), Sonia de Castro (Autor), Margarita Menéndez (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Cationic ultrashort lipopeptides (USLPs) are promising antimicrobial candidates to combat multidrug-resistant bacteria. Using DICAMs, a newly synthesized family of tripeptides with net charges from −2 to +1 and a fatty amine conjugated to the C-terminus, we demonstrate that anionic and neutral zwitt...