A novel ω-conotoxin Bu8 inhibiting N-type voltage-gated calcium channels displays potent analgesic activity

• Main Authors: Jinqin Chen (Author), Xinhong Liu (Author), Shuo Yu (Author), Jia Liu (Author), Rongfang Chen (Author), Yunxiao Zhang (Author), Ling Jiang (Author), Qiuyun Dai (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ω-Conotoxins inhibit N-type voltage-gated calcium (CaV2.2) channels and exhibit efficacy in attenuating neuropathic pain but have a low therapeutic index. Here, we synthesized and characterized a novel ω-conotoxin, Bu8 from Conus bullatus, which consists of 25 amino acid residues and three disulfide...