Mitochondrial DNA Release Contributes to Intestinal Ischemia/Reperfusion Injury

• Main Authors: Shishi Liao (Author), Jie Luo (Author), Tulanisa Kadier (Author), Ke Ding (Author), Rong Chen (Author), Qingtao Meng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondria release many damage-associated molecular patterns (DAMPs) when cells are damaged or stressed, with mitochondrial DNA (mtDNA) being. MtDNA activates innate immune responses and induces inflammation through the TLR-9, NLRP3 inflammasome, and cGAS-STING signaling pathways. Released inflamm...