Validation of Pharmacological Protocols for Targeted Inhibition of Canalicular MRP2 Activity in Hepatocytes Using [^99mTc]mebrofenin Imaging in Rats

• Main Authors: Solène Marie (Author), Irene Hernández-Lozano (Author), Louise Breuil (Author), Wadad Saba (Author), Anthony Novell (Author), Jean-Luc Gennisson (Author), Oliver Langer (Author), Charles Truillet (Author), Nicolas Tournier (Author)
• Format: Book
• Published: MDPI AG, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The multidrug resistance-associated protein 2 (MRP2) mediates the biliary excretion of drugs and metabolites. [^99mTc]mebrofenin may be employed as a probe for hepatic MRP2 activity because its biliary excretion is predominantly mediated by this transporter. As the liver uptake...