Dysregulation of Blood-Brain Barrier and Exacerbated Inflammatory Response in Cx47-Deficient Mice after Induction of EAE

• Glavni autori: Filippos Stavropoulos (Autor), Elena Georgiou (Autor), Irene Sargiannidou (Autor), Kleopas A. Kleopa (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2021-06-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Induction of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), in connexin 32 (Cx32) or Cx47 knockout (KO) mice with deficiency in oligodendrocyte gap junctions (GJs) results in a more severe disease course. In particular, Cx47 KO EAE mice experience an ear...