An image-based high-content screening assay for compounds targeting intracellular Leishmania donovani amastigotes in human macrophages.

• Main Authors: Jair L Siqueira-Neto (Author), Seunghyun Moon (Author), Jiyeon Jang (Author), Gyongseon Yang (Author), Changbok Lee (Author), Hong Kee Moon (Author), Eric Chatelain (Author), Auguste Genovesio (Author), Jonathan Cechetto (Author), Lucio H Freitas-Junior (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leishmaniasis is a tropical disease threatening 350 million people from endemic regions. The available drugs for treatment are inadequate, with limitations such as serious side effects, parasite resistance or high cost. Driven by this need for new drugs, we developed a high-content, high-throughput...