DAKS1, a Kunitz Scaffold Peptide from the Venom Gland of <i>Deinagkistrodon acutus</i> Prevents Carotid-Artery and Middle-Cerebral-Artery Thrombosis via Targeting Factor XIa

• Main Authors: Zhiping Jia (Author), Yunyang Liu (Author), Xiaoru Ji (Author), Yizheng Zheng (Author), Zhengyang Li (Author), Shuai Jiang (Author), Hongjin Li (Author), Yi Kong (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Scaffold-based peptides (SBPs) are fragments of large proteins that are characterized by potent bioactivity, high thermostability, and low immunogenicity. Some SBPs have been approved by the FDA for human use. In the present study, we developed SBPs from the venom gland of <i>Deinagkistrodon a...